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Model Agnostic Interpretability for Multiple Instance Learning

About

In Multiple Instance Learning (MIL), models are trained using bags of instances, where only a single label is provided for each bag. A bag label is often only determined by a handful of key instances within a bag, making it difficult to interpret what information a classifier is using to make decisions. In this work, we establish the key requirements for interpreting MIL models. We then go on to develop several model-agnostic approaches that meet these requirements. Our methods are compared against existing inherently interpretable MIL models on several datasets, and achieve an increase in interpretability accuracy of up to 30%. We also examine the ability of the methods to identify interactions between instances and scale to larger datasets, improving their applicability to real-world problems.

Joseph Early, Christine Evers, Sarvapali Ramchurn• 2022

Related benchmarks

TaskDatasetResultRank
Histopathology Image ClassificationNSCLC (test)
AUROC (Test)96
22
Tumor localizationCAMELYON16 (test)
AUC95
20
MIL Explanation4-Bags (test)
AUPRC0.89
16
MIL ExplanationPos-Neg (test)
AUPRC0.91
16
MIL ExplanationAdjacent Pairs (test)
AUPRC (Class 2)77
15
Biomarker PredictionLUAD TP53 (test)
AUPC73
12
Biomarker PredictionHNSC HPV (test)
AUPC92
12
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