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ODE Discovery for Longitudinal Heterogeneous Treatment Effects Inference

About

Inferring unbiased treatment effects has received widespread attention in the machine learning community. In recent years, our community has proposed numerous solutions in standard settings, high-dimensional treatment settings, and even longitudinal settings. While very diverse, the solution has mostly relied on neural networks for inference and simultaneous correction of assignment bias. New approaches typically build on top of previous approaches by proposing new (or refined) architectures and learning algorithms. However, the end result -- a neural-network-based inference machine -- remains unchallenged. In this paper, we introduce a different type of solution in the longitudinal setting: a closed-form ordinary differential equation (ODE). While we still rely on continuous optimization to learn an ODE, the resulting inference machine is no longer a neural network. Doing so yields several advantages such as interpretability, irregular sampling, and a different set of identification assumptions. Above all, we consider the introduction of a completely new type of solution to be our most important contribution as it may spark entirely new innovations in treatment effects in general. We facilitate this by formulating our contribution as a framework that can transform any ODE discovery method into a treatment effects method.

Krzysztof Kacprzyk, Samuel Holt, Jeroen Berrevoets, Zhaozhi Qian, Mihaela van der Schaar• 2024

Related benchmarks

TaskDatasetResultRank
Continuous-Time Treatment OptimizationCancer Explicit
Avg Spearman Correlation-0.77
3
Continuous-Time Treatment OptimizationCancer Relative
Avg Spearman Correlation-0.78
3
Continuous-Time Treatment OptimizationCovid-19 Target Trajectory
Avg Spearman Correlation0.43
3
Treatment OptimizationCancer Explicit
Average True Cost559.7
3
Treatment OptimizationCancer Relative
Avg True Cost333.8
3
Treatment OptimizationCovid-19 Target Trajectory
Average True Cost7.59
3
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