CXPMRG-Bench: Pre-training and Benchmarking for X-ray Medical Report Generation on CheXpert Plus Dataset

X-ray image-based medical report generation (MRG) is a pivotal area in artificial intelligence which can significantly reduce diagnostic burdens and patient wait times. Despite significant progress, we believe that the task has reached a bottleneck due to the limited benchmark datasets and the existing large models' insufficient capability enhancements in this specialized domain. Specifically, the recently released CheXpert Plus dataset lacks comparative evaluation algorithms and their results, providing only the dataset itself. This situation makes the training, evaluation, and comparison of subsequent algorithms challenging. Thus, we conduct a comprehensive benchmarking of existing mainstream X-ray report generation models and large language models (LLMs), on the CheXpert Plus dataset. We believe that the proposed benchmark can provide a solid comparative basis for subsequent algorithms and serve as a guide for researchers to quickly grasp the state-of-the-art models in this field. More importantly, we propose a large model for the X-ray image report generation using a multi-stage pre-training strategy, including self-supervised autoregressive generation and Xray-report contrastive learning, and supervised fine-tuning. Extensive experimental results indicate that the autoregressive pre-training based on Mamba effectively encodes X-ray images, and the image-text contrastive pre-training further aligns the feature spaces, achieving better experimental results. Source code can be found on \url{https://github.com/Event-AHU/Medical_Image_Analysis}.