TeamMedAgents: Enhancing Medical Decision-Making of LLMs Through Structured Teamwork

We present TeamMedAgents, a modular multi-agent framework that systematically translates evidence-based teamwork principles from organizational psychology into large language model collaboration for medical decision-making. Building upon Salas et al.'s "Big Five" teamwork model, we operationalize five core components as independently configurable mechanisms: shared mental models, team leadership, team orientation, trust networks, and mutual monitoring. Our architecture dynamically recruits 2-4 specialist agents and employs structured four-phase deliberation with adaptive component selection. Evaluation across eight medical benchmarks encompassing 11,545 questions demonstrates TeamMedAgents achieves 77.63% overall accuracy (text-based: 81.30%, vision-language: 66.60%). Systematic ablation studies comparing three single-agent baselines (Zero-Shot, Few-Shot, CoT) against individual teamwork components reveal task-specific optimization patterns: shared mental models excel on knowledge tasks, trust mechanisms improve differential diagnosis, while comprehensive integration degrades performance. Adaptive component selection yields 2-10 percentage point improvements over strongest baselines, with 96.2% agent convergence validating structured coordination effectiveness. TeamMedAgents establishes principled methodology for translating human teamwork theory into multi-agent systems, demonstrating that evidence-based collaboration patterns enhance AI performance in safety-critical domains through modular component design and selective activation strategies.