LFRA-Net: A Lightweight Focal and Region-Aware Attention Network for Retinal Vessel Segmentatio

Retinal vessel segmentation is critical for the early diagnosis of vision-threatening and systemic diseases, especially in real-world clinical settings with limited computational resources. Although significant improvements have been made in deep learning-based segmentation methods, current models still face challenges in extracting tiny vessels and suffer from high computational costs. In this study, we present LFRA-Net by incorporating focal modulation attention at the encoder-decoder bottleneck and region-aware attention in the selective skip connections. LFRA-Net is a lightweight network optimized for precise and effective retinal vascular segmentation. It enhances feature representation and regional focus by efficiently capturing local and global dependencies. LFRA-Net outperformed many state-of-the-art models while maintaining lightweight characteristics with only 0.17 million parameters, 0.66 MB memory size, and 10.50 GFLOPs. We validated it on three publicly available datasets: DRIVE, STARE, and CHASE\_DB. It performed better in terms of Dice score (84.28\%, 88.44\%, and 85.50\%) and Jaccard index (72.86\%, 79.31\%, and 74.70\%) on the DRIVE, STARE, and CHASE\_DB datasets, respectively. LFRA-Net provides an ideal ratio between segmentation accuracy and computational cost compared to existing deep learning methods, which makes it suitable for real-time clinical applications in areas with limited resources. The code can be found at https://github.com/Mehwish4593/LFRA-Net.