SciReasoner: Laying the Scientific Reasoning Ground Across Disciplines
About
We present a scientific reasoning foundation model that aligns natural language with heterogeneous scientific representations. The model is pretrained on a 206B-token corpus spanning scientific text, pure sequences, and sequence-text pairs, then aligned via SFT on 40M instructions, annealed cold-start bootstrapping to elicit long-form chain-of-thought, and reinforcement learning with task-specific reward shaping, which instills deliberate scientific reasoning. It supports four capability families, covering up to 103 tasks across workflows: (i) faithful translation between text and scientific formats, (ii) text/knowledge extraction, (iii) property prediction, (iv) property classification, (v) unconditional and conditional sequence generation and design. Compared with specialist systems, our approach broadens instruction coverage, improves cross-domain generalization, and enhances fidelity. We detail data curation and training and show that cross-discipline learning strengthens transfer and downstream reliability. The model, instruct tuning datasets and the evaluation code are open-sourced at https://huggingface.co/SciReason and https://github.com/open-sciencelab/SciReason.
Related benchmarks
| Task | Dataset | Result | Rank | |
|---|---|---|---|---|
| Forward synthesis | SMolInstruct | Exact Match75 | 23 | |
| Protein-related instruction tasks | Mol-Instructions | Protein Function ROUGE-L53.21 | 22 | |
| Property Prediction | SMolInstruct Lipo | Lipo RMSE0.82 | 19 | |
| Captioning | SMolInstruct | METEOR60 | 19 | |
| Property Prediction | SMolInstruct BBBP | BBBP Accuracy82.74 | 19 | |
| Property Prediction | SMolInstruct ESOL | ESOL RMSE1.08 | 19 | |
| Property Prediction | SMolInstruct ClinTox | ClinTox Accuracy92.36 | 19 | |
| Name Conversion | SMolInstruct | -- | 15 | |
| Molecular Name Conversion (SMILES-to-IUPAC) | SMolInstruct | Exact Match56.63 | 12 | |
| Retrosynthesis | SMolInstruct | EM46 | 12 |