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DriftLite: Lightweight Drift Control for Inference-Time Scaling of Diffusion Models

About

We study inference-time scaling for diffusion models, where the goal is to adapt a pre-trained model to new target distributions without retraining. Existing guidance-based methods are simple but introduce bias, while particle-based corrections suffer from weight degeneracy and high computational cost. We introduce DriftLite, a lightweight, training-free particle-based approach that steers the inference dynamics on the fly with provably optimal stability control. DriftLite exploits a previously unexplored degree of freedom in the Fokker-Planck equation between the drift and particle potential, and yields two practical instantiations: Variance- and Energy-Controlling Guidance (VCG/ECG) for approximating the optimal drift with minimal overhead. Across Gaussian mixture models, particle systems, and large-scale protein-ligand co-folding problems, DriftLite consistently reduces variance and improves sample quality over pure guidance and sequential Monte Carlo baselines. These results highlight a principled, efficient route toward scalable inference-time adaptation of diffusion models. Our source code is publicly available at https://github.com/yinuoren/DriftLite.

Yinuo Ren, Wenhao Gao, Lexing Ying, Grant M. Rotskoff, Jiequn Han• 2025

Related benchmarks

TaskDatasetResultRank
Particle System SamplingDW-4 Annealing
∆NLL-0.043
4
Particle System SamplingDW-4 Reward-Tilting
Delta NLL0.296
4
Particle System SamplingLJ-13 Annealing
∆NLL-1.084
4
Particle System SamplingLJ-13 Reward-Tilting
Delta NLL1.734
4
Protein-ligand co-foldingPoseBuster V2 (test)
Valid Fraction85.6
4
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