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Code Like Humans: A Multi-Agent Solution for Medical Coding

About

In medical coding, experts map unstructured clinical notes to alphanumeric codes for diagnoses and procedures. We introduce Code Like Humans: a new agentic framework for medical coding with large language models. It implements official coding guidelines for human experts, and it is the first solution that can support the full ICD-10 coding system (+70K labels). It achieves the best performance to date on rare diagnosis codes (fine-tuned discriminative classifiers retain an advantage for high-frequency codes, to which they are limited). Towards future work, we also contribute an analysis of system performance and identify its `blind spots' (codes that are systematically undercoded).

Andreas Motzfeldt, Joakim Edin, Casper L. Christensen, Christian Hardmeier, Lars Maal{\o}e, Anna Rogers• 2025

Related benchmarks

TaskDatasetResultRank
Medical CodingACI (non-PHI)
Recall56
7
Full code system evaluationCorti proprietary AMB
Recall51.1
5
Full code system evaluationCorti proprietary ED
Recall26.5
5
Medical CodingMDACE
Recall30.7
5
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