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Demo: Generative AI helps Radiotherapy Planning with User Preference

About

Radiotherapy planning is a highly complex process that often varies significantly across institutions and individual planners. Most existing deep learning approaches for 3D dose prediction rely on reference plans as ground truth during training, which can inadvertently bias models toward specific planning styles or institutional preferences. In this study, we introduce a novel generative model that predicts 3D dose distributions based solely on user-defined preference flavors. These customizable preferences enable planners to prioritize specific trade-offs between organs-at-risk (OARs) and planning target volumes (PTVs), offering greater flexibility and personalization. Designed for seamless integration with clinical treatment planning systems, our approach assists users in generating high-quality plans efficiently. Comparative evaluations demonstrate that our method can surpasses the Varian RapidPlan model in both adaptability and plan quality in some scenarios.

Riqiang Gao, Simon Arberet, Martin Kraus, Han Liu, Wilko FAR Verbakel, Dorin Comaniciu, Florin-Cristian Ghesu, Ali Kamen• 2025

Related benchmarks

TaskDatasetResultRank
Plan Quality ComparisonRadiotherapy Plans Small (val)
Plans Better (%)100
21
OAR sparing assessmentRT Plan Dataset (test)
Better Sparing (%)71.11
15
DVH PredictionInter-patient cohort IMRT (test)
Spinal Cord (05)0.73
6
PTV homogeneity and conformity assessmentRT Plan Dataset (test)
PTV Conformity Better (%)4.29
6
Dose Volume Histogram (DVH) PredictionHead-and-neck cancer cases Cohorts 0-5 Internal (test)
SpinalCord05 (Dose)1.18
4
Intra-patient DVH difference evaluationIMRT-planned radiotherapy dataset
Spinal Cord DVH Diff1.63
4
Dose Volume Histogram (DVH) PredictionSmall Inter-patient Sets (val)
Spinal Cord (05) Dose Metric0.12
4
Intra-patient DVH difference analysisSmall (val)
Spinal Cord D05 Difference1.57
4
OAR Dosimetric Quality EvaluationHead and Neck Radiotherapy Plans
Spinal Cord (05)6.49
3
PTV Dosimetric Quality EvaluationHead and Neck Radiotherapy Plans
HI (PTVHigh)1.3
3
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