Progressive $\mathcal{J}$-Invariant Self-supervised Learning for Low-Dose CT Denoising

Self-supervised learning has been increasingly investigated for low-dose computed tomography (LDCT) image denoising, as it alleviates the dependence on paired normal-dose CT (NDCT) data, which are often difficult to collect. However, many existing self-supervised blind-spot denoising methods suffer from training inefficiencies and suboptimal performance due to restricted receptive fields. To mitigate this issue, we propose a novel Progressive $\mathcal{J}$-invariant Learning that maximizes the use of $\mathcal{J}$-invariant to enhance LDCT denoising performance. We introduce a step-wise blind-spot denoising mechanism that enforces conditional independence in a progressive manner, enabling more fine-grained learning for denoising. Furthermore, we explicitly inject a combination of controlled Gaussian and Poisson noise during training to regularize the denoising process and mitigate overfitting. Extensive experiments on the Mayo LDCT dataset demonstrate that the proposed method consistently outperforms existing self-supervised approaches and achieves performance comparable to, or better than, several representative supervised denoising methods.