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Omni-fMRI: A Universal Atlas-Free fMRI Foundation Model

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Self-supervised fMRI foundation models have shown promising transfer performance, yet most rely on predefined region-level parcellations that discard fine-grained voxel information and introduce atlas-dependent biases. We propose Omni-fMRI, an atlas-free foundation model that operates directly on voxel-level signals. To enable scalable pretraining on 49,497 fMRI sessions across nine datasets, Omni-fMRI introduces a dynamic patching mechanism that substantially reduces computational cost while preserving informative spatial structure. To support reproducibility and fair comparison, we establish a comprehensive benchmark suite spanning 11 datasets and a diverse set of resting-state and task-based fMRI tasks. Experimental results demonstrate that Omni-fMRI consistently outperforms existing foundation models, providing a scalable and reproducible framework for atlas-free brain representation learning. Code and logs are available.

Mo Wang, Wenhao Ye, Junfeng Xia, Junxiang Zhang, Xuanye Pan, Minghao Xu, Haotian Deng, Hongkai Wen, Quanying Liu• 2026

Related benchmarks

TaskDatasetResultRank
Age regressionSALD
Mean Squared Error (MSE)0.182
23
Gender ClassificationABCD
Accuracy77.01
22
Disease DiagnosisADNI MCI
Accuracy63.4
19
Brain Age PredictionNKI
MSE0.088
12
Gender ClassificationBHRC
Accuracy75.86
12
Age regressionABIDE
MSE0.427
12
Education ClassificationNKI
Accuracy68.13
11
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