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CUPID: A Plug-in Framework for Joint Aleatoric and Epistemic Uncertainty Estimation with a Single Model

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Accurate estimation of uncertainty in deep learning is critical for deploying models in high-stakes domains such as medical diagnosis and autonomous decision-making, where overconfident predictions can lead to harmful outcomes. In practice, understanding the reason behind a model's uncertainty and the type of uncertainty it represents can support risk-aware decisions, enhance user trust, and guide additional data collection. However, many existing methods only address a single type of uncertainty or require modifications and retraining of the base model, making them difficult to adopt in real-world systems. We introduce CUPID (Comprehensive Uncertainty Plug-in estImation moDel), a general-purpose module that jointly estimates aleatoric and epistemic uncertainty without modifying or retraining the base model. CUPID can be flexibly inserted into any layer of a pretrained network. It models aleatoric uncertainty through a learned Bayesian identity mapping and captures epistemic uncertainty by analyzing the model's internal responses to structured perturbations. We evaluate CUPID across a range of tasks, including classification, regression, and out-of-distribution detection. The results show that it consistently delivers competitive performance while offering layer-wise insights into the origins of uncertainty. By making uncertainty estimation modular, interpretable, and model-agnostic, CUPID supports more transparent and trustworthy AI. Related code and data are available at https://github.com/a-Fomalhaut-a/CUPID.

Xinran Xu, Xiuyi Fan• 2026

Related benchmarks

TaskDatasetResultRank
OOD DetectionCIFAR10
AUC98.3
28
Misclassification DetectionGL V2
AUC87
9
Misclassification DetectionHAM10000
AUC85.5
9
OOD DetectionPAPILA
AUC87.7
9
OOD DetectionACRIMA
AUC97.8
9
OOD DetectionACRIMA
OOD-UCE22.6
9
OOD DetectionCIFAR-10
OOD UCE0.273
9
Medical Image ClassificationHAM10000 (test)
AUC0.952
7
Uncertainty Estimation in Image Super-ResolutionSet5 (test)
Pearson Correlation52.8
7
Uncertainty Estimation in Image Super-ResolutionSet14 (test)
Pearson Correlation Coefficient0.527
7
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