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Fitness Prediction on ProteinGym (overall)

0.519Spearman Correlation

EvoIF-MSA

Updated 5d ago

Evaluation Results

Method
EvoIF-MSA 2025.10	0.519	78.4	0.409	79.6	24.6
VenusREM 2025.10	0.518	78.3	0.404	77	24.4
AIDO Protein-RAG 2025.10	0.518	78.4	0.405	78.9	23.9
ProtSST (K=2048) 2025.10	0.507	77.7	0.398	77.4	23.6
S3F-MSA 2024.12	0.496	77.1	0.387	79.2	24.4
S3F-MSA 2025.10	0.496	77.1	0.387	79.2	24.4
EvoIF 2025.10	0.489	76.8	0.384	78.2	25
S2F-MSA 2024.12	0.487	76.7	0.381	79	24
S2F-MSA 2025.10	0.487	76.7	0.381	79	24
S3F 2024.12	0.47	75.7	0.371	77	23.4
S3F 2025.10	0.47	75.7	0.371	77	23.4
SaProt 2024.12	0.457	75.1	0.359	76.8	23.3
SaProt 2025.10	0.457	75.1	0.359	76.8	23.3
TranceptEVE L 2024.12	0.456	75.1	0.356	78.6	23
TranceptEVE L 2025.10	0.456	75.1	0.356	78.6	23
GEMME 2024.12	0.455	74.9	0.352	77.7	21.1
GEMME 2025.10	0.455	74.9	0.352	77.7	21.1
S2F 2024.12	0.454	74.9	0.359	76.2	22.7
S2F 2025.10	0.454	74.9	0.359	76.2	22.7
ProtSSN 2024.12	0.442	74.3	0.351	76.4	22.6
ProtSSN 2025.10	0.442	74.3	0.351	76.4	22.6
EVE 2024.12	0.439	74.1	0.342	78.3	23
EVE 2025.10	0.439	74.1	0.342	78.3	23
MSA Transformer 2024.12	0.434	73.8	0.34	77.9	22.4
Tranception L 2024.12	0.434	73.9	0.341	77.9	22
MSA Transformer 2025.10	0.434	73.8	0.34	77.9	22.4
Tranception L 2025.10	0.434	73.9	0.341	77.9	22
ESM-IF 2024.12	0.422	73	0.331	74.8	22.3
ESM-IF 2025.10	0.422	73	0.331	74.8	22.3
DeepSequence 2024.12	0.419	72.9	0.328	77.6	22.6
DeepSequence 2025.10	0.419	72.9	0.328	77.6	22.6
ESM2 2024.12	0.414	72.9	0.327	74.7	21.7
ESM-2 2025.10	0.414	72.9	0.327	74.7	21.7
ProGen2 XL 2024.12	0.391	71.7	0.306	76.7	19.9
ProGen2 XL 2025.10	0.391	71.7	0.306	76.7	19.9
MIF 2024.12	0.383	70.6	0.294	74.3	21.6
MIF-ST 2024.12	0.383	71.7	0.31	76.5	22.6
MIF 2025.10	0.383	70.6	0.294	74.3	21.6
MIF-ST 2025.10	0.383	71.7	0.31	76.5	22.6
CARP 2024.12	0.368	70.1	0.285	74.8	20.8
CARP 2025.10	0.368	70.1	0.285	74.8	20.8
ProteinMPNN 2024.12	0.258	63.9	0.196	71.3	18.6
ProteinMPNN 2025.10	0.258	63.9	0.196	71.3	18.6