| Dataset Name | SOTA Method | Metric | Trend | ||
|---|---|---|---|---|---|
| SKEMPI v2.0 | RedNet | Spearman ρ0.28 | 30 | 21d ago | |
| SKEMPI2 (all mutations) | DiffAffinity | Pearson Corr (Overall)0.669 | 24 | 3mo ago | |
| PDBBind core set 2016 (test) | Transformer-M | R0.83 | 17 | 3mo ago | |
| CSAR-HiQ | HBGSA | RMSE1.603 | 15 | 1mo ago | |
| LBA | Ours | RMSE1.276 | 14 | 1mo ago | |
| SKEMPI2 single mutations | DiffAffinity | Pearson Correlation (Overall)0.672 | 12 | 3mo ago | |
| CASF 2016 (test) | SS-GNN | Rp0.853 | 11 | 3mo ago | |
| MISATO (sequence split) | AminoAseed | R^20.466 | 10 | 20d ago | |
| binding affinity prediction Downstream task 3 protein-level (five-fold cross-validation) | CryoProt | RMSE0.486 | 8 | 1d ago | |
| Shaneh Sequence length 120 | Spearman Correlation0.536 | 7 | 3mo ago | ||
| Shaneh Sequence length 119 | CoSiNE | Spearman Correlation0.498 | 7 | 3mo ago | |
| Koenig L (Light chain mutation) | CoSiNE | Spearman Correlation0.371 | 7 | 3mo ago | |
| Koenig (Heavy chain mutation) | CoSiNE | Spearman Correlation0.456 | 7 | 3mo ago | |
| PDBbind 2016 (core set) | SIGN | RMSE1.316 | 5 | 3mo ago | |
| SARS-CoV-2 RBD (PDB ID: 6M0J) (285 single-point mutations) | DiffAffinity | Pearson R0.466 | 4 | 3mo ago | |
| TP53 PDB 2VUK | Binding Affinity (kcal/mol)7.09 | 3 | 16d ago | ||
| SMAD3 PDB 1U7F | Binding Affinity (kcal/mol)7.28 | 3 | 16d ago | ||
| PIK3CA PDB 7PG6 | Binding Affinity (kcal/mol)7.33 | 3 | 16d ago | ||
| MTOR PDB 4JT6 | Binding Affinity (kcal/mol)7.09 | 3 | 16d ago | ||
| HDAC1 PDB 4BKX | CURE | Binding Affinity8.68 | 3 | 16d ago | |
| EGFR PDB 1M17 | Binding Affinity (kcal/mol)7.3 | 3 | 16d ago | ||
| CTSK PDB 1VSN | Binding Affinity7.55 | 3 | 16d ago | ||
| AURKB PDB 4C2V | Binding Affinity (kcal/mol)7.4 | 3 | 16d ago | ||
| AKT2 PDB 2JDR | Binding Affinity (kcal/mol)7.48 | 3 | 16d ago | ||
| AKT1 PDB 3O96 | Binding Affinity (kcal/mol)7.45 | 3 | 16d ago |
